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Facile, catalyst-free, microwave-assisted access toward the synthesis of 2-aryl/alkyl-3-(1H-benzo[d]imidazol-2-yl)-2, 3-dihydroquinazolin-4(1H)-ones

Authors
  • Kumar, Prashant
  • Matta, Akanksha
  • Singh, Snigdha
  • Van der Eycken, Johan
  • Len, Christophe
  • Parmar, Virinder S.
  • Van der Eycken, Erik V.
  • Singh, Brajendra K.
Publication Date
2017
Source
Ghent University Institutional Archive
Keywords
License
Unknown
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Abstract

An efficient, catalyst-free, microwave-assisted approach has been developed for the synthesis of 2-aryl/alkyl-3-(1H-benzo[d]imidazol-2yl)-2,3-dihydroquinazolin-4(1H)-one derivatives by condensing 2-aminobenzamides with various aliphatic, aromatic, and heterocyclic aldehydes. This catalyst-free approach exhibited good functional group compatibility and produced the desired products in good to excellent yields in just 10-20 min. This approach can be seen as a better alternative of the metal-catalyzed protocols used for the synthesis of this class of compounds. The formation of desired compound has also been confirmed by X-ray analysis.

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