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Synthesis of 1-(dihydroxypropyl)-5-substituted uracils

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
44
Issue
39
Identifiers
DOI: 10.1016/s0040-4039(03)01872-0
Keywords
  • 1-(Dihydroxypropyl)-5-Substituted Uracils
  • Aminopropanediols
  • Enantiomers

Abstract

Abstract Novel 1-(dihydroxypropyl)-5-substituted uracils were synthesized in the reaction of 1-(4-nitrophenyl)-5-substituted uracil derivatives with appropriate aminopropanediols under mild conditions. In the case of 3-amino-1,2-propanediol both racemic and enantiomerically enriched products were obtained. These compounds may be considered as new building blocks for oligonucleotide synthesis.

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