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Genotypic analysis of plasmid-mediated β-lactamases amongst Enterobacteriaceae other thanEscherichiaspp. andKlebsiellaspp. that are non-susceptible to a broad-spectrum cephalosporin

Authors
Journal
International Journal of Antimicrobial Agents
0924-8579
Publisher
Elsevier
Publication Date
Volume
36
Issue
4
Identifiers
DOI: 10.1016/j.ijantimicag.2010.06.029
Keywords
  • Enterobacteriaceae
  • Cephalosporins
  • β-Lactamase
  • Esbl
  • Ampc
  • Carbapenemase
Disciplines
  • Biology

Abstract

Abstract Enterobacteriaceae other than Escherichia spp. and Klebsiella spp. are recognisable for their increasing resistance. Plasmid-mediated β-lactamases, including extended-spectrum β-lactamases (ESBLs), plasmid-mediated AmpC β-lactamases (pAmpCs) and the newly emerged KPC, play an important role in β-lactam resistance. In this study, we investigated the genetic characteristics of plasmid-mediated β-lactamases amongst non- Escherichia, non- Klebsiella Enterobacteriaceae that were non-susceptible to at least a broad-spectrum cephalosporin. A total of 143 (23.9%) of 598 isolates during the 6-month study period met the screening criteria, amongst which 142 (99.3%) and 99 (69.2%) isolates carried ESBL and pAmpC genes, respectively. Resistance genotypes were described. bla KPC was not detected in isolates with reduced susceptibility to carbapenems. This study provides an insight into plasmid-mediated resistance determinants amongst cephalosporin-non-susceptible Enterobacteriaceae other than Escherichia spp. and Klebsiella spp.

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