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Fabrication of polyethyleneimine modified magnetic microporous organic network nanosphere for efficient enrichment of non-steroidal anti-inflammatory drugs from wastewater samples prior to HPLC-UV analysis.

Authors
  • He, Xin-Qiao1
  • Cui, Yuan-Yuan1
  • Lin, Xiao-Hui2
  • Yang, Cheng-Xiong3
  • 1 College of Chemistry, Research Center for Analytical Sciences, Tianjin Key Laboratory of Biosensing and Molecular Recognition, Nankai University, Tianjin, 300071, China. , (China)
  • 2 Department of Physics and Chemistry, Tianjin Centers for Disease Control and Prevention, Tianjin, 300011, China. , (China)
  • 3 College of Chemistry, Research Center for Analytical Sciences, Tianjin Key Laboratory of Biosensing and Molecular Recognition, Nankai University, Tianjin, 300071, China. Electronic address: [email protected]. , (China)
Type
Published Article
Journal
Talanta
Publication Date
Oct 01, 2021
Volume
233
Pages
122471–122471
Identifiers
DOI: 10.1016/j.talanta.2021.122471
PMID: 34215105
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Development of novel functionalized adsorbents for efficient magnetic solid phase extraction (MSPE) is essential for promoting their versatile applications in sample pretreatment. Herein, we report the fabrication of a new polyethyleneimine-600 decorated magnetic microporous organic network nanosphere (Fe3O4@MON-PEI600) for effective MSPE of trace non-steroidal anti-inflammatory drugs (NSAIDs) from different water samples. The core-shelled Fe3O4@MON-PEI600 integrates the synergistic effects of Fe3O4, MON and PEI600, providing facile and effective extraction to NSAIDs via multiple hydrogen bonding, π-π and hydrophobic interactions. The inner MON shell employs π-π and hydrophobic interaction sites and the outer PEI-600 coat acts as the hydrogen bonding doner/receptor, which affords good extraction performance for NSAIDs. Under optimal conditions, the Fe3O4@MON-PEI600-MSPE-HPLC-UV method gives wide linear range (0.14-400 μg L-1), low limits of detection (0.042-0.149 μg L-1), good precisions (intra-day and inter-day RSDs < 4.5%, n = 6), and large enrichment factors (97.0-98.2). Extraction mechanisms and selectivity of Fe3O4@MON-PEI600 are evaluated in detail. Moreover, Fe3O4@MON-PEI600 is successfully applied to enrich the trace NSAIDs in different water samples with the concentrations of 0.7 and 0.8 μg L-1 for 1-naphthylacetic acid, 0.5 and 0.1 μg L-1 for naproxen as well as 0.7 μg L-1 for ibuprofen, respectively. The developed method not only affords a novel and efficient magnetic adsorbent for NSAIDs in aqueous media at trace level, but also provides a new strategy for the rational design and synthesis of multiple functionalized MON composites in sample pretreatment. Copyright © 2021 Elsevier B.V. All rights reserved.

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