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Fabrication of N-doped multidimensional carbon nanofibers for high-performance cortisol biosensors.

Authors
  • Jeong, Goeen1
  • Oh, Jungkyun1
  • Jang, Jyongsik2
  • 1 School of Chemical and Biological Engineering, College of Engineering, Seoul National University, 1 Gwanakro, Gwanakgu, Seoul 08826, Republic of Korea. , (North Korea)
  • 2 School of Chemical and Biological Engineering, College of Engineering, Seoul National University, 1 Gwanakro, Gwanakgu, Seoul 08826, Republic of Korea. Electronic address: [email protected] , (North Korea)
Type
Published Article
Journal
Biosensors & bioelectronics
Publication Date
Apr 15, 2019
Volume
131
Pages
30–36
Identifiers
DOI: 10.1016/j.bios.2019.01.061
PMID: 30802785
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Cortisol is an hormone that regulates blood pressure, glucose levels and carbohydrate metabolism in humans. Abnormal secretion of cortisol can cause various symptoms closely linked to psychological and physical health. In this study, high-performance field-effect transistor (FET)-based biosensors for cortisol detection were fabricated from N-doped multidimensional carbon nanofibers. Nanofiber morphology was controlled by tailoring the pressure conditions during vapor deposition polymerization (VDP). Thereafter, conductive channels of FET were completed by thermal annealing, acid treatment, and antibody attachment. Changes associated with chemical processes were characterized by various instruments. The resulting transducers exhibited a rapid response toward cortisol molecules with accurate selectivity, stable reusability, and high sensitivity. Minimum detection level were as low as 100 aM with a wide linear detection range of 100 aM to 10 nM due to the large surface area of the transducer and a correspondingly high number of antibody labels. The response and applicability of these cortisol biosensors were also assessed using saliva as a test matrix. Copyright © 2019. Published by Elsevier B.V.

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