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Fabrication and evaluation of calcium phosphate cement scaffold with controlled internal channel architecture and complex shape.

Authors
  • Li, X1
  • Li, D
  • Lu, B
  • Wang, L
  • Wang, Z
  • 1 State Key Laboratory for Manufacturing Systems Engineering, Xi'an Jiaotong University, Xi'an, People's Republic of China. [email protected] , (China)
Type
Published Article
Journal
Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
Publication Date
Nov 01, 2007
Volume
221
Issue
8
Pages
951–958
Identifiers
PMID: 18161255
Source
Medline
License
Unknown

Abstract

The ability to have precise control over internal channel architecture, porosity, and external shape is essential for tissue engineering. The feasibility of using indirect stereo-lithography (SL) to produce scaffolds from calcium phosphate cement materials for bone tissue engineering has been investigated. The internal channel architecture of the scaffolds was created by removal of the negative resin moulds made with SL. Scanning electron microscopy (SEM) showed highly open, well-interconnected channel architecture. The X-ray diffraction examination revealed that the hydroxyapatite phase formed at room temperature in the cement was basically stable up to 850 degrees C. There was no phase decomposition of hydroxyapatite, although the crystallinity and grain size were different. The ability of resulting structure to support osteoblastic cells culture was tested in vitro. Cells were evenly distributed on exterior surfaces and grew into the internal channels of scaffolds. To exploit the ability of this technique, anatomically shaped femoral supracondylar scaffolds with 300-800 microm interconnected channels were produced and characterized.

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