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Fabrication of deoxycholic acid tethered α-cyanostilbenes as smart low molecular weight gelators and AIEE probes for bio-imaging.

Authors
  • Agarwal, Devesh S1
  • Prakash Singh, Rajnish2
  • Jha, Prabhat N2
  • Sakhuja, Rajeev3
  • 1 Department of Chemistry, Birla Institute of Technology and Science, Pilani 333 031, Rajasthan, India. , (India)
  • 2 Department of Biological Sciences, Birla Institute of Technology and Science, Pilani 333 031, Rajasthan, India. , (India)
  • 3 Department of Chemistry, Birla Institute of Technology and Science, Pilani 333 031, Rajasthan, India. Electronic address: [email protected] , (India)
Type
Published Article
Journal
Steroids
Publication Date
Aug 01, 2020
Volume
160
Pages
108659–108659
Identifiers
DOI: 10.1016/j.steroids.2020.108659
PMID: 32439407
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Four novel deoxycholic acid tethered α-cyanostilbenes were designed, synthesized and characterized using detailed spectroscopic analysis. The synthesized deoxycholic acid tethered α-cyanostilbene derivatives formed stable gels with a variety of solvents, such as xylene, toluene, mesitylene, decane, dodecane etc. The stable gels showed lamellar sheet type structures stacked over each other, consisting of entangled fibres as evident from SEM, TEM and Fluorescence Microscopy images; The synthesized compounds exhibited AIEE behaviour in H2O/THF mixture, with the maximum emission observed in 70% H2O/THF fraction along with a bathochromic shift. A solvent thickening experiment was perform to establish the mechanism of AIEE and the AIEE property was explored for bacterial bio-imaging. The synthesized derivatized steroids proved their potential as multifunctional organic materials. Copyright © 2020 Elsevier Inc. All rights reserved.

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