Affordable Access

Publisher Website

Responsiveness of normal and dystrophic avian muscle to acetylcholine, carbamylcholine andd-tubocurarine

Authors
Journal
General Pharmacology The Vascular System
0306-3623
Publisher
Elsevier
Publication Date
Volume
19
Issue
5
Identifiers
DOI: 10.1016/0306-3623(88)90131-0

Abstract

Abstract 1. 1. The responsiveness of dystrophic avian muscle to acetylcholine may be altered due to reported elevated acetylcholinesterase activity. 2. 2. To test this hypothesis, the responsiveness of normal and dystrophic muscle in vivo to intra-arterial injection of acetylcholine, carbamylcholine and d-tubocurarine was compared. 3. 3. Results showed that dystrophic muscle was less responsive to acetylcholine, more responsive d-tubocurarine and equally responsive to carbamylcholine when compared to normal suggesting enhanced acetylcholine hydrolysis occurs in vivo in dystrophic avian muscle.

There are no comments yet on this publication. Be the first to share your thoughts.