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Spread of CTX-M–type extended-spectrum β-lactamases among bloodstream isolates ofEscherichia coliandKlebsiella pneumoniaefrom a Korean hospital

Authors
Journal
Diagnostic Microbiology and Infectious Disease
0732-8893
Publisher
Elsevier
Publication Date
Volume
63
Issue
1
Identifiers
DOI: 10.1016/j.diagmicrobio.2008.09.002
Keywords
  • Ctx-M-14
  • Ctx-M-15
  • Ctx-M-24
  • Ctx-M-65
  • Ctx-M-27
  • Ctx-M-32
  • Korea

Abstract

Abstract This study was to determine the prevalence and characteristics of CTX-M–type extended-spectrum β-lactamases (ESBLs) in nonduplicate Escherichia coli ( n = 760) and Klebsiella pneumoniae ( n = 379) bloodstream isolates collected during January 2005 to October 2007 at a university hospital (2000 beds) in Seoul, Korea. Antimicrobial susceptibilities were determined by disk diffusion and agar dilution methods. The double-disk synergy test detected ESBLs in 8.7% (66/760) of E. coli and 11.3% (43/379) of K. pneumoniae isolates. Polymerase chain reaction detected bla CTX-M in 60/66 (90.9%) E. coli and 9/43 (20.9%) K. pneumoniae isolates with the ESBL phenotype. CTX-M-14 was the most common type of CTX-M ESBLs in both E. coli ( n = 32) and K. pneumoniae ( n = 6). CTX-M-15 was the 2nd most common type of CTX-M ESBLs in E. coli ( n = 22), but it was not detected in K. pneumoniae. In addition, CTX-M-24 ( n = 2), CTX-M-65 ( n = 2), CTX-M-27 ( n = 1), and CTX-M-32 ( n = 1) were detected for the 1st time in Korea.

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