Affordable Access

Publisher Website

The eosinophil and the pathophysiology of asthma

Authors
Journal
Journal of Allergy and Clinical Immunology
0091-6749
Publisher
Elsevier
Publication Date
Volume
77
Issue
4
Identifiers
DOI: 10.1016/0091-6749(86)90341-6
Keywords
  • Postgraduate Course
Disciplines
  • Biology

Abstract

Abstract Eosinophilia of lung and blood associated with injury to the mucociliary escalator and excessive shedding of bronchial epithelium are hallmarks of both allergic and nonallergic asthma. In vitro, the eosinophil granule major basic protein (MBP) is toxic to helminths and to mammalian cells, including human respiratory epithelium. The MBP-mediated damage to the respiratory epithelium consists of desquamation and frank destruction of ciliated cells. Increased sputum MBP concentration is a good marker for asthma, and patients treated for acute asthma have high levels of MBP in their sputa, which decrease after treatment. Peak sputum MBP levels approximate concentrations toxic to respiratory epithelium in vitro. In the lungs of patients who had died of asthma, MBP has been localized outside of the eosinophil in association with damage to the epithelium. Overall, these and other findings suggest the hypothesis that the eosinophil mediates damage to the respiratory epithelium and is the prime effector cell in the pathophysiology of asthma.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

The eosinophil and the pathophysiology of asthma.

on Journal of Allergy and Clinica... April 1986

The role of eosinophils in the pathophysiology of...

on Annals of the New York Academy... 1991

Roles of eosinophils and catecholamines in pathoph...

on Pediatric allergy and immunolo... November 1993

Eosinophils in asthma.

on Chinese medical journal May 2004
More articles like this..