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Epidermal growth factor inhibits both cholecystokinin octapeptide-induced inositol 1,4,5-trisphosphate production and [Ca2+]iincrease in rat pancreatic acinar cells

Authors
Journal
Biochemical and Biophysical Research Communications
0006-291X
Publisher
Elsevier
Publication Date
Volume
180
Issue
2
Identifiers
DOI: 10.1016/s0006-291x(05)81150-7

Abstract

Summary We have studied the effects of epidermal growth factor (EGF) on both cholecystokinin octapeptide (CCK-OP)-induced inositol-1,4,5 trisphosphate (IP 3) production and on cytosolic free calcium concentrations [Ca 2+] i by fluorescence measurements in fura-2-loaded pancreatic acini. Our data show that EGF inhibits CCK-OP induced IP 3 production by 40 ± 9 % and decreases CCK-OP induced rise in cytosolic Ca 2+ by 41 ± 9 %. These data indicate that activation of EGF receptors leads to inhibition of CCK-OP induced stimulation of phospholipase C (PLC).

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