Affordable Access

Publisher Website

TP53Status and Gene Amplification in Human Colorectal Carcinomas

Authors
Journal
Cancer Genetics and Cytogenetics
0165-4608
Publisher
Elsevier
Publication Date
Volume
115
Issue
2
Identifiers
DOI: 10.1016/s0165-4608(99)00073-4
Disciplines
  • Biology
  • Medicine

Abstract

Abstract Gene amplification is one of the characteristics of cancer cells. In vitro studies suggested that alterations of the TP53 gene might be responsible for gene amplification. We have examined the presence of TP53 mutations and looked for cytogenetic evidence of gene amplification in a series of 79 primary colorectal carcinomas. Other parameters such as the pattern of cytogenetic alterations, microsatellite instability, tumor site, and histological staging were also considered. A multiparametric study supported by statistical analyses suggests the existence of two major pathways of colorectal carcinogenesis. No relationships could be established between the presence of TP53 alterations and gene amplification.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

TP53 status and gene amplification in human colore...

on Cancer Genetics and Cytogeneti... December 1999

MDM2 gene amplification and transcript levels in h...

on JNCI Journal of the National C... Sep 07, 1994

TP53: a key gene in human cancer.

on Biochimie January 2002

TP53: a key gene in human cancer

on Biochimie Jan 01, 2002
More articles like this..