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Further exploration of antimicrobial ketodihydronicotinic acid derivatives by multiple parallel syntheses

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Bentham Science Publishers Ltd.
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Keywords
  • A Synthetic Reexamination Of A Series Of Ketodihydronicotinic Acid Class Antibacterial Agents Was Un
  • A Convenient New Synthesis Was Developed Involving Hetero Diels-Alder Chemistry Producing 74 New Ana
  • Several Compounds Demonstrated Significant Broad-Spectrum Activity Against Clinically Derived Bacter
  • 4-Difluorophenyl)-6-(4-Dimethylaminophenyl)-4-Pyridone-3-Carboxylic Acid (7) Remained The Most Poten
  • Cross-Resistance With Ciprofloxacin Supported A Commonality Of Mode Of Action
  • Permiabilization Of Escherichia Coli Cells By Polymyxin B Significantly Enhanced Potency With These

Abstract

Further exploration of antimicrobial ketodihydronicotinic acid derivatives by multiple parallel syntheses - DTU Orbit (18/04/14) Further exploration of antimicrobial ketodihydronicotinic acid derivatives by multiple parallel syntheses - DTU Orbit (18/04/14) Laursen, JB, Nielsen, J, Haack, T, Pusuluri, S, David, S, Balakrishna, R, Zeng, YB, Ma, ZK, Doyle, TB & Mitscher, LA 2006, 'Further exploration of antimicrobial ketodihydronicotinic acid derivatives by multiple parallel syntheses' Combinatorial Chemistry & High Throughput Screening, vol 9, no. 9, pp. 663-681., 10.2174/138620706778700107

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