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Analog-induced inclusions in pancreatic acinar cells

Authors
Journal
Journal of Ultrastructure Research
0022-5320
Publisher
Elsevier
Publication Date
Volume
7
Identifiers
DOI: 10.1016/s0022-5320(62)90023-0
Disciplines
  • Biology

Abstract

Feeding of β-3-thienyl- dl-alanine in semisynthetic diets devoid of phenylalanine produces characteristic focal areas of cytoplasmic necrosis. The cytoplasmic components within sequestered areas give rise to myeloid structures and small granules within complex dense bodies. Further alteration of the contents of complex dense bodies results in appearance of homogeneous bodies. This process appears to be related to a disturbed protein synthesis and to formation of abnormal proteins; it may represent a mechanism by which the cell eliminates abnormal proteins of endogenous and exogenous origin.

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