Affordable Access

Publisher Website

The potencies of optically active anaesthetics

Authors
Journal
European Journal of Medicinal Chemistry
0223-5234
Publisher
Elsevier
Publication Date
Volume
30
Issue
9
Identifiers
DOI: 10.1016/0223-5234(96)88291-2
Keywords
  • Anaesthetic
  • Optical Activity
  • Molecular Similarity
  • Calculation
Disciplines
  • Design
  • Philosophy

Abstract

Summary Calculations of the molecular similarity between pairs of enantiomeric general anaesthetics lead to a measure of the degree of chirality. Those based on shape similarity suggest that isoflurane is likely to show more difference in potency between chiral forms than are desflurane, enflurane, or halothane, while calculations based on molecular electrostatic potential (MEP) indicate that enflurane is likely to show more difference in potency between chiral form than the other three. These calculations have potential for identifying anaesthetics that are more active in optically pure forms, as well as for revealing more about the nature of their active site.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Optically active doped xerogel

on Journal of Non-Crystalline Sol... Jan 01, 1992

Are lignins optically active?

on Journal of Agricultural and Fo... August 1999
More articles like this..