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Synaptic terminals wrapped in the somatic cytoplasm of pigmented neurons in the human locus ceruleus

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
188
Issue
3
Identifiers
DOI: 10.1016/0304-3940(95)11416-t
Keywords
  • Humans
  • Locus Ceruleus
  • Pigmented Neuron
  • Synaptic Terminal
  • Synaptic Vesicle-Specific 38-Kda Protein
  • Immunocytocytochemistry
Disciplines
  • Biology
  • Chemistry

Abstract

Abstract We examined the locus ceruleus (LC) of 59 autopsied individuals whose ages at death ranged from 5 to 108 years. Immunocytochemistry with synaptic vesicle-specific 38-kDa protein (SVP) revealed that clusters of SVP-like immunoreactive coarse granules were present in the somatic cytoplasm of some pigmented neurons in all individuals examined. These SVP-like immunoreactive granules were confirmed electron microscopically to be contained in synaptic terminals which were wrapped in the somatic cytoplasm of pigmented LC neurons.

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