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Using a biology-based model: interest and recommendations

Authors
Publication Date
Keywords
  • Modele
  • Essai
  • Variation
  • Daphnie
  • Zinc
  • Debtox
Disciplines
  • Biology
  • Mathematics

Abstract

The conventional analysis of bioassays often neglects biological significance. However, mathematical equations with few pararneters but realistic from a biological point of view do exist to describe toxicokinetics and effects on test organisrns of chernical compounds. Here we studied a biologybased model (DEBtox) which provides an estirnate of a No Effect Concentration. First,we showed the ability of the basic model to be extended to give a proper answer to problerns usually faced during bioassays like tirne-varying concentrations or unsuited choice of initial concentrations. Téreach this goal we produced experimental data from Daphnia magna exposed to zinc. These data also showed the potential interest of the model to understand the infiuence of food on toxicity. We also gave sorne recommendations about the choice of initial concentrations and we proposed a test with a depuration period to check the relevancy and the predictive capacity of the DEBtox model. In our experiments, it passed the test and has been confirmed to be a very precious tool in risk assessment. / Les modèles actuels d'analyse des bioessais ont rarement le souci de la pertinence biologique. Il existe pourtant des équations mathématiques comportant peu de paramètres mais réalistes d'un point de vue biologique pour décrire la cinétique d'un composé et ses effets sur les organismes testés. Nous étudions ici les potentialités d'un modèle à fondement biologique (DEBtox). Il permet en théorie de prendre en compte les variations de la concentration au cours du temps, d'étudier de façon pertinente les effets de la nourriture, et de prédire les effets des contaminants, même dans des conditions variables d'exposition. Une série d'expériences avec la daphnie et le zinc confirment très largement ces spéculations.

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