Affordable Access

Publisher Website

Role of B cells in systemic lupus erythematosus and rheumatoid arthritis

Authors
Journal
Current Opinion in Immunology
0952-7915
Publisher
Elsevier
Publication Date
Volume
20
Issue
6
Identifiers
DOI: 10.1016/j.coi.2008.08.003
Disciplines
  • Biology
  • Medicine

Abstract

B cell tolerance to many self-proteins is actively maintained by either purging self-reactive B receptors through clonal deletion and receptor editing, or by functional silencing known as anergy. However, these processes are clearly incomplete as B cell driven autoimmune diseases still occur. The significance of B cells in two such diseases, rheumatoid arthritis and systemic lupus erythematosus, is highlighted by the ameliorative effects of B cell depletion. It remains to be determined, however, whether the key role of the B cell in autoimmune disease is autoantibody production or another antibody-independent function.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Possible role of adipokines in systemic lupus eryt...

on Revista Brasileira de Reumatol... 2012

The role of stress and trauma in rheumatoid arthri...

on Seminars in arthritis and rheu... February 1987

The role of stress and trauma in rheumatoid arthri...

on Seminars in Arthritis and Rheu... Jan 01, 1987

Th17 cells in rheumatoid arthritis and systemic lu...

on Journal of internal medicine June 2009
More articles like this..