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Carboxylation of hydroxy aromatic compounds

DOI: 10.1016/s0926-9614(96)80014-1


Publisher Summary The carboxylation of hydroxyaromatic compounds in the form of alkaline salts (the Kolbe Schmitt reaction) is well known and applied in the synthesis of acids such as salicylic acid, para-hydroxybenzoic acid and ortho-cresotinic acid. Kolbe first produced salicylic acid by heating a mixture of phenol and sodium in the presence of carbon dioxide at atmospheric pressure. After that the importance of CO2 pressure, temperature of the system and the role of water was highlighted.

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