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Role of Central Serotonin in Impulsivity and Compulsivity: Comparative Studies in Experimental Animals and Humans-CHAPTER 3.8

Elsevier Science & Technology
DOI: 10.1016/s1569-7339(10)70093-x
  • Impulsivity
  • Compulsivity
  • Behavioral Inhibition
  • Striatum
  • Prefrontal Cortex
  • Adhd
  • Obsessive-Compulsive Disorder
  • Medicine


Abstract The involvement of serotonin in impulsivity (the tendency to respond prematurely) and compulsivity (the tendency to perseverate) is reviewed from the joint perspective of animal and human studies. Evidence is provided to support a role for serotonin in some forms of impulsivity, but not others, and in compulsivity. However, it is difficult to accommodate these roles into a common scheme implicating behavioral inhibition. The implications for neuropsychiatric disorders such as obsessive-compulsive disorder are considered.

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