Abstract Advanced oxidation processes (AOPs) for degrading disperse dyes were developed to utilize nano-iron modified goldmine waste-solid as the heterogeneous catalyst for a Fenton-like oxidation. The removal performance of Dispersed Orange 288 effluent was investigated by homogeneous catalyzed Fenton reactions as well as heterogeneous adsorption for raw and modified goldmine waste-solid. And maximal DOC removal is 32.3% when 9 g modified goldmine waste-solid was added in 100 ml solution in heterogeneous adsorption process. While in the nanoiron modified goldmine waste-solid assisted AOPs, it is found that combination of adsorption treatment and advanced oxidation processes exhibits the stronger degradation capacity. By varying concentration of H2O2 from 10 to 50 ml/L, the COD removal of Dispersed Orange 288 effluent under 3 g modified goldmine waste-solid was observed being increased from 20.3 to 68.6%.