Affordable Access

Publisher Website

Does DNA repair occur during somatic hypermutation?

Authors
Journal
Seminars in Immunology
1044-5323
Publisher
Elsevier
Volume
24
Issue
4
Identifiers
DOI: 10.1016/j.smim.2012.05.002
Keywords
  • Activation-Induced Deaminase
  • Base Excision Repair
  • Mismatch Repair
  • Dna Polymerases
Disciplines
  • Biology

Abstract

Abstract Activation-induced deaminase (AID) initiates a flood of DNA damage in the immunoglobulin loci, leading to abasic sites, single-strand breaks and mismatches. It is compelling that some proteins in the canonical base excision and mismatch repair pathways have been hijacked to increase mutagenesis during somatic hypermutation. Thus, the AID-induced mutagenic pathways involve a mix of DNA repair proteins and low fidelity DNA polymerases to create antibody diversity. In this review, we analyze the roles of base excision repair, mismatch repair, and mutagenesis during somatic hypermutation of rearranged variable genes. The emerging view is that faithful base excision repair occurs simultaneously with mutagenesis, whereas faithful mismatch repair is mostly absent.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Balancing AID and DNA repair during somatic hyperm...

on Trends in Immunology Jan 01, 2009

Error-prone DNA repair activity during somatic hyp...

on The Journal of Immunology Nov 01, 2010

Somatic hypermutation: subverted DNA repair

on Current Opinion in Immunology Jan 01, 2006

DNA repair in antibody somatic hypermutation.

on Trends in immunology July 2006
More articles like this..