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CXCR3 expression on peripheral CD4+T cells as a predictive marker of response to treatment in chronic hepatitis C

Authors
Journal
Clinical Immunology
1521-6616
Publisher
Elsevier
Publication Date
Volume
132
Issue
1
Identifiers
DOI: 10.1016/j.clim.2009.03.521
Keywords
  • Hcv
  • Ccr5
  • Chemokine Receptor
  • Interferon
  • Ribavirin
  • Aspartate Aminotransferase
  • Liver Fibrosis
  • Hcv Load
Disciplines
  • Medicine

Abstract

Abstract We monitored in fifty individuals with chronic hepatitis C (CHC) the expression of CCR5 and CXCR3, two chemokine receptors involved in the intra-hepatic recruitment of T cells, at the surface of circulating CD4 + T cells. The percentage of CD4 + T cells expressing CCR5 and/or CXCR3 was increased in patients. The increased percentage of CD4 + CXCR3 + T lymphocytes was linked to serum level of aspartate aminotransferase (AST) and to fibrosis METAVIR score. CD4 + T cell surface CCR5 and CXCR3 densities increased after 6 months of treatment with pegylated interferon-α and ribavirin. The pre-therapeutic percentage of CD4 + CXCR3 + T cells was correlated with alanine aminotransferase serum level at 12 months, and viral load at 24 months after treatment initiation. Thus, in CHC we observed a high CXCR3 expression on peripheral blood CD4 + T cells which correlates with AST serum level and liver fibrosis, and is predictive of the response to treatment.

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