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Effects of carbachol and nicotine injected into the cerebral ventricles on electromyogram of conscious cats

Authors
Journal
Brain Research Bulletin
0361-9230
Publisher
Elsevier
Publication Date
Volume
2
Issue
1
Identifiers
DOI: 10.1016/0361-9230(77)90030-2
Keywords
  • Carbachol
  • Nicotine
  • Intraventricular Injections
  • Electromyogram
  • Electrooculogram
  • Nicotinic And Muscarinic Mediations

Abstract

Abstract Carbachol and nicotine injected into the cerebral ventricles produced high amplitude and fast frequency activity in the electromyogram of conscious cats. Carbachol, much more than nicotine, caused bursts of such activity spaced at irregular time intervals accompanied by marked activity in the electrooculogram. In addition carbachol, but not nicotine, caused adynamia. The effect of nicotine lasted 3–5 hr, while the effect of carbachol lasted up to 6 hr. The obtained results suggest that central muscarinic and nicotinic mediations are involved in the activation of the motor efferent system.

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