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Therapeutic capacity of the synthetic peptide-based vaccine againstTaenia soliumcysticercosis in pigs

Authors
Journal
Vaccine
0264-410X
Publisher
Elsevier
Publication Date
Volume
23
Issue
31
Identifiers
DOI: 10.1016/j.vaccine.2004.11.076
Keywords
  • Taenia Solium
  • Therapeutic Vaccine
  • Protection
  • Pig Cysticercosis
Disciplines
  • Biology
  • Medicine

Abstract

Abstract The S3Pvac synthetic vaccine composed of three peptides (GK1, KETc1 and KETc12) effectively protect against pig cysticercosis. Preliminary results point to an additional cysticidal capacity induced by S3Pvac or GK1 immunization. Herein, clear evidences of the cysticidal effect of S3Pvac but not of GK1 are presented. S3Pvac immunization of already experimentally infected pigs induced a reduction in the parasite load, in the vesicular cysticerci and in their viability. It also substantially increases the percent of histological damaged cysticerci more importantly in muscles than in brains, with a concomitant reduction in the antibody levels. Thus, S3Pvac represents a powerful means of controlling cysticercosis infection in pigs.

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