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Convenient two-step stereospecific hydroxy-substitution with retention in β-hydroxy-δ-lactones. 4 (R)-heterosubstituted mevinolin and -analogs

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
27
Issue
39
Identifiers
DOI: 10.1016/s0040-4039(00)85044-3

Abstract

Abstract Michael additions of mercaptanes and amines to optically pure 6- alkyl-5,6-dihydro-2H-pyran-2-ones of the mevinolin type [6( R )]- 5 and the aromatic analog [6(S)]- 7 are stereospecific to give 4 ( R )-substituted mevinolin analogs.

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