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Effect of insulin on glucose metabolism of the ex vivo perfused canine liver

Authors
Journal
Journal of Surgical Research
0022-4804
Publisher
Elsevier
Publication Date
Volume
4
Issue
6
Identifiers
DOI: 10.1016/s0022-4804(64)80044-5

Abstract

Summary o 1. The livers of eight fasting dogs were perfused with oxygenated homologous blood in an isolated perfusion chamber to determine whether insulin altered the hepatic utilization of glucose. 2. No significant effect of insulin on hepatic glucose utilization was noted. 3. Factors that affect previous experiments are discussed and emphasis is placed upon utilizing a preparation totally free from interfering feedback stimuli. 4. A short discussion is given relating to the actual site of insulin activity in light of these paradoxical findings.

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