Affordable Access

Mouse subspecies differentiation and H-2 polymorphism

Biological Journal of the Linnean Society
Oxford University Press
Publication Date
  • Mus Musculus
  • H-2
  • Subspecific Differentiation


Abstract Four major groups of Mus musculus subspecies are analysed from the genetical view point. A number of genetic traits exhibited polymorphism. Most were common among domesticus, bactrianus and castaneus subspecies, while others were musculus subspecies-specific. This suggests that the earliest differentiation was between domesticus and musculus. Mouse class I MHC was compared in these two lines. Immunological and molecular analyses of H-2K molecules indicated that these two groups of mouse have several common haplotypes of class I molecules. Phenotype frequencies of these haplotypes are considerably different in each subspecies. “Overdominance selection” in class I H-2 is one of the possible explanations for this.

There are no comments yet on this publication. Be the first to share your thoughts.


Seen <100 times

More articles like this

Regulation of phospholipase C activation by the nu...

on Biochemical Pharmacology Jan 01, 2002

Polymorphism in boron deposited by the H2reduction...

on Journal of the Less Common Met... Jan 01, 1979
More articles like this..