Affordable Access

Mouse subspecies differentiation and H-2 polymorphism

Authors
Journal
Biological Journal of the Linnean Society
0024-4066
Publisher
Oxford University Press
Publication Date
Keywords
  • Mus Musculus
  • H-2
  • Subspecific Differentiation

Abstract

Abstract Four major groups of Mus musculus subspecies are analysed from the genetical view point. A number of genetic traits exhibited polymorphism. Most were common among domesticus, bactrianus and castaneus subspecies, while others were musculus subspecies-specific. This suggests that the earliest differentiation was between domesticus and musculus. Mouse class I MHC was compared in these two lines. Immunological and molecular analyses of H-2K molecules indicated that these two groups of mouse have several common haplotypes of class I molecules. Phenotype frequencies of these haplotypes are considerably different in each subspecies. “Overdominance selection” in class I H-2 is one of the possible explanations for this.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments