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New classes of antibacterial oxazolidinones with C-5, methyleneO-Linked heterocyclic side chains

Authors
Journal
Bioorganic & Medicinal Chemistry Letters
0960-894X
Publisher
Elsevier
Publication Date
Volume
13
Issue
23
Identifiers
DOI: 10.1016/j.bmcl.2003.07.033

Abstract

Abstract Exploration of the structure–activity relationships of the traditional C-5 acetamidomethyl side chain of the oxazolidonone antibacterials has yielded new, potent series of compounds of which the first examples, the O-linked iosoxazoles are described in detail, leading to the selection of the pre-clinical candidate AZD2563.

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