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Magnetic resonance spectroscopy of normal appearing white matter in early relapsing-remitting multiple sclerosis: correlations between disability and spectroscopy

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BioMed Central
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PMC
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  • Research Article

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1471-2377-4-8.fm ral ss BioMed CentBMC Neurology Open AcceResearch article Magnetic resonance spectroscopy of normal appearing white matter in early relapsing-remitting multiple sclerosis: correlations between disability and spectroscopy Juan Luis Ruiz-Peña1, Pilar Piñero2,8, Guillermo Sellers3, Joaquín Argente4, Alfredo Casado5, Jesus Foronda6, Antonio Uclés7 and Guillermo Izquierdo*1 Address: 1Unidad de Esclerosis Múltiple, Hospital Universitario Virgen Macarena, Avda, Dr, Fedriani 3, 41003 Sevilla, España, 2Servicio de Radiología, Clínica Sagrado Corazón, Rafael Salgado 3, 41013 Sevilla, España, 3Centro de Investigación y Bioestadística, Trespaderne, 29, Edif, Barajas, 1, 28042 Madrid, España, 4Servicio de Neurología, Hospital Puerta del Mar, Avda, de viva, 21, 11009 Cádiz, España, 5Servicio de Neurología, Hospital San Cecilio, Avda, Dr., Oloriz, 16, 18012 Granada, España, 6Servicio de Neurología, Hospital de Jaén, Avda, Del Ejercito Español, 10, 23007 Jaén, España, 7Servicio de Neurología, Hospital Virgen del Rocío, Avda, Manuel Siurot s/n, 41013 Sevilla, España and 8Servicio de Radiología, Hospital Virgen del Rocío, Avda, Manuel Siurot s/n, 41013 Sevilla, España Email: Juan Luis Ruiz-Peña - [email protected]; Pilar Piñero - [email protected]; Guillermo Sellers - [email protected]; Joaquín Argente - [email protected]; Alfredo Casado - [email protected]; Jesus Foronda - [email protected]; Antonio Uclés - [email protected]; Guillermo Izquierdo* - [email protected] * Corresponding author Abstract Background: What currently appears to be irreversible axonal loss in normal appearing white matter, measured by proton magnetic resonance spectroscopy is of great interest in the study of Multiple Sclerosis. Our aim is to determine the axonal damage in normal appearing white matter measured by magnetic resonance spectroscopy and to correlate this with the functional disability measured by Multiple Sclerosis Functional Compos

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