Abstract Objectives To describe a Communication Skills Laboratory and assess student performance, ability to meet North American Pharmacist Licensure Examination (NAPLEX) blueprint competency statements, and student confidence in communication-related patient care activities. Design Essential elements of pharmacist communication, Counseling, Drug Information, and Written Documentation, were incorporated into a Communication Lab. Student performance was assessed using grading rubrics and scores. A student survey assessed how effectively the curricula met the NAPLEX blueprint objectives and perceptions of confidence in performing communication tasks. Assessment Performance, assessed via student grades, improved significantly in the three main activities of the lab (p < 0.001, p < 0.001, and p < 0.001). Pre- and post-laboratory surveys were completed by 89% and 87% of students, respectively. Student’s mean scores assessing the curriculum’s ability to meet NAPLEX competencies increased significantly from 3.40 to 3.80. Mean score in confidence rating increased significantly from 2.83 to 3.75. Conclusion A Communication Skills Laboratory improved student performance, met NAPLEX competencies, and increased self-rating in confidence in patient care activities involving communication.