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Interaction of sulfur mustard with rat liver salt fractionated chromatin

Authors
Journal
International Journal of Biological Macromolecules
0141-8130
Publisher
Elsevier
Publication Date
Volume
46
Issue
1
Identifiers
DOI: 10.1016/j.ijbiomac.2009.10.006
Keywords
  • Sulfur Mustard
  • Active And Inactive Chromatin
  • Rat Liver

Abstract

Abstract In this study, the interaction of an alkylating agent, sulfur mustard (SM) with rat liver active (S 1 and S 2) and inactive (P 2) chromatin was investigated employing UV/vis spectroscopy and gel electrophoreses. The results show that SM affects the chromatin structure in a dose-dependent manner. The binding of SM to fractions is different. At lower concentrations (<500 μM), SM seems to unfold the structure and at higher concentrations, it induces aggregation and condensation of chromatin possibly via forming cross-links between the chromatin components. The extent of condensation in S 2 is higher when compared to the P 2 fraction.

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