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Cortisol receptors in rabbit fetal lung

Authors
Journal
Biochemical and Biophysical Research Communications
0006-291X
Publisher
Elsevier
Publication Date
Volume
47
Issue
2
Identifiers
DOI: 10.1016/0006-291x(72)90729-2
Disciplines
  • Biology
  • Medicine

Abstract

Abstract Rabbit fetal lung nuclei contain macromolecules which have the properties of physiological receptors for cortisol by the criteria of specificity of binding and saturation of binding sites at low concentrations of the hormone The number of nuclear receptor sites is relatively low at 20 days of gestation, reaches a maximum at about 28–30 days of gestation and drops slightly after birth. These results correlate well with previously reported changes in pulmonary epithelial cell maturation and surfactant concentrations in rabbit fetal lung extracts. Preliminary evidence for the presence of cytoplasmic cortisol-binding components in fetal lung cells is also presented.

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