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Quantification of L-type fatty acid binding protein in the urine of preterm neonates

Authors
Journal
Early Human Development
0378-3782
Publisher
Elsevier
Publication Date
Volume
81
Issue
7
Identifiers
DOI: 10.1016/j.earlhumdev.2005.03.012
Keywords
  • L-Type Fatty Acid Binding Protein
  • Oxidative Stress
  • Preterm Neonate
  • Urine
Disciplines
  • Biology

Abstract

Abstract We measured urinary excretion of L-type fatty acid binding protein (L-FABP) in preterm neonates on days 1, 5–10, and 25–30 of life. Urinary L-FABP levels (expressed as the ratio to creatinine) in preterm neonates were considerably higher than those of healthy adults. They did not change significantly during the study period. Urinary L-FABP levels showed significant positive correlation with those of urinary N-acetyl-beta- d-glucosaminidase activity on day 1, and with those of 8-hydroxy-2′-deoxyguanosine on days 25–30. These results suggest that L-FABP is expressed in the neonatal kidney. Our results may also point to potential effects of proximal tubular damage and oxidative stress on urinary excretion of L-FABP.

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