Affordable Access

Publisher Website

Quantification of the compactibility of pharmaceutical powders

Authors
Journal
European Journal of Pharmaceutics and Biopharmaceutics
0939-6411
Publisher
Elsevier
Publication Date
Volume
63
Issue
3
Identifiers
DOI: 10.1016/j.ejpb.2005.10.012
Keywords
  • Compactibility
  • Methodology
  • Mathematical Models
  • Specific Crushing Strength
  • Walker Equation
  • Compressibility
Disciplines
  • Logic
  • Pharmacology

Abstract

Abstract The purpose of this study is to investigate and to quantify the compactibility of pharmaceutical powders by a simple linear relationship between the diametral compressive strength of tablets and the applied compaction pressure. The mechanical strength of the tablets is characterized as the crushing force normalized with the dimension of the tablet and termed the specific crushing strength, SCS. The proposed model: SCS = Cp ∗ P + b estimates the slope of the regression line Cp as a dimensionless compactibility parameter and is reported with the corresponding standard deviation S Cp. The linear region of the compactibility profile is selected using the 95% predictability limits bordering the regression line. Eleven different materials were tested and acceptable fits to the linear model were observed in all cases. The ability of the model to discriminate between the investigated materials is excellent, in cases where the difference may be difficult to show a simple t-test is used as an inference tool. No difference was found between lactose tablets of different masses (500 and 1000 mg). A relationship between the compactibility parameter and the compressibility characterized by the Walker coefficient is demonstrated.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Quantification of the compactibility of pharmaceut...

on European Journal of Pharmaceut... July 2006

Fundamentals of powder compression. I. The compact...

on Pharmaceutical Research February 1986

Image analysis quantification of sticking and pick...

on Pharmaceutical Research September 2013

Compressibility and compactibility of powdered pol...

on European Journal of Pharmaceut... Jan 01, 1997
More articles like this..