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Hemodynamics of the experimental dumping syndrome

Authors
Journal
Surgery
0039-6060
Publisher
Elsevier
Publication Date
Keywords
  • Investigative Surgery

Abstract

Abstract The effects of 5 percent glucose, and 50 percent glucose, and 50 percent mannose upon mesenteric hemodynamics and intestinal fluid volume were studied in anesthetized dogs in an attempt to evaluate certain theoretical considerations of the dumping syndrome. Both hypertonic solutions drew large volumes of fluid into the gut which resulted in vomiting and diarrhea. Hypertonic glucose alone increased mesenteric blood flow. The movement of a large volume of fluid into the intestine in response to a load of hypertonic glucose and at the expense of plasma water, that is accompanied by a rise in blood flow to the gut, remains the most likely explanation of the dumping syndrome.

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