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Hyperplasia of hepatic bile ducts in mice following long-term administration of butylated hydroxytoluene

Authors
Journal
Food and Cosmetics Toxicology
0015-6264
Publisher
Elsevier
Publication Date
Volume
11
Issue
5
Identifiers
DOI: 10.1016/0015-6264(73)90143-0

Abstract

Abstract Six of 18 male BALB/c mice regularly givena diet containing 0·75% butylated hydroxytoluene (BHT) and killed at 12 months of age showed a marked hyperplasia of the hepatic bile ducts, with an associated subacute cholangitis. None of the 64 untreated control mice nor 19 BHT-treated control mice that additionally received diethylnitrosamine in their drinking-water, developed proliferation of the bile-duct epithelium. While the cause, pathogenesis and fate of the observed lesion is uncertain, further investigation is needed to determine the possible hazard arising from long-term human consumption of BHT.

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