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C2-symmetrical sterol–polyether conjugates as highly efficient synthetic ionophores

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
44
Issue
32
Identifiers
DOI: 10.1016/s0040-4039(03)01454-0
Keywords
  • Ionophore
  • Steroid
  • Amphiphiles
Disciplines
  • Design

Abstract

Abstract A new class of artificial ionophores has been rationally designed and synthesized linking to a tetrafunctionalized l-treitol spacer two rigid hydrophobic 3β-hydroxy-5α-23,24-bisnorcholanic units and two flexible hydrophilic oligo(ethylene glycol) chains. Compounds 1a and 1b were incorporated into phospholipid vesicles and shown to facilitate Na +-transport.

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