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Species-specific differences in the expression of the HNF1A, HNF1B and HNF4A genes.

Authors
Journal
PLoS ONE
1932-6203
Publisher
Public Library of Science
Publication Date
Volume
4
Issue
11
Identifiers
DOI: 10.1371/journal.pone.0007855
Keywords
  • Adult
  • Alternative Splicing
  • Animals
  • Female
  • Gene Expression Profiling
  • Gene Expression Regulation
  • Hepatocyte Nuclear Factor 1-Alpha
  • Hepatocyte Nuclear Factor 1-Beta
  • Hepatocyte Nuclear Factor 4
  • Humans
  • Islets Of Langerhans
  • Male
  • Mice
  • Mice
  • Inbred Balb C
  • Middle Aged
  • Rats
  • Rats
  • Wistar
  • Species Specificity

Abstract

The HNF1A, HNF1B and HNF4A genes are part of an autoregulatory network in mammalian pancreas, liver, kidney and gut. The layout of this network appears to be similar in rodents and humans, but inactivation of HNF1A, HNF1B or HNF4A genes in animal models cause divergent phenotypes to those seen in man. We hypothesised that some differences may arise from variation in the expression profile of alternatively processed isoforms between species.

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