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Signal sequences:The limits of variation

Authors
Journal
Journal of Molecular Biology
0022-2836
Publisher
Elsevier
Publication Date
Volume
184
Issue
1
Identifiers
DOI: 10.1016/0022-2836(85)90046-4

Abstract

Abstract Variations in length and composition of the charged N-terminal, central hydrophobic and polar C-terminal regions in a large sample of signal sequences have been mapped, both as a function of the overall length of the sequence, and in an absolute sense, i.e. various “extremes” have been sought. The results show subtle differences between eukaryotic and prokaryotic sequences, but the general impression of signal sequences as being highly variable is reinforced. Criteria for a “minimal” signal sequence are suggested and discussed.

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