Coccidioidomycosis occurs in arid and semi-arid regions of the New World from the western United States to Argentina. Highly endemic areas are present in the southwest United States. Coccidioides species live in the soil and produce pulmonary infection via airborne arthroconidia. The skin may be involved by dissemination of the infection, or by reactive eruptions, such as a generalized exanthem or erythema nodosum. Interstitial granulomatous dermatitis and Sweet's syndrome have recently been recognized as additional reactive signs of the infection. Coccidioidomycosis is a “great imitator” with protean manifestations. Cutaneous findings may be helpful clues in the diagnosis of this increasingly important disease. Learning objective At the conclusion of this learning activity, participants should be familiar with the pathogenesis, clinical manifestations, risk factors, diagnosis, and treatment of coccidioidomycosis.