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Neuroendocrine regulation of GnRH release and expression of GnRH and GnRH receptor genes in the hypothalamus-pituitary unit in different physiological states

Authors
Journal
Reproductive Biology
1642-431X
Publisher
Elsevier
Volume
10
Issue
2
Identifiers
DOI: 10.1016/s1642-431x(12)60054-0
Keywords
  • Ewe
  • Hypothalamus
  • Gnrh Mrna
  • Gnrhr Mrna
  • Lh
Disciplines
  • Biology
  • Medicine

Abstract

SUMMARY This review is focused on the relationship between neuroendocrine regulation of GnRH/LH secretion and the expression of GnRH and GnRH receptor (GnRHR) genes in the hypothalamic-pituitary unit during different physiological states of animals and under stress. Moreover, the involvement of hypothalamic GABA-ergic, β-endorphinergic, CRH-ergic, noradrenergic, dopaminergic and GnRH-ergic systems in the regulation of expression of the GnRH and GnRHR genes as well as secretion of GnRH/LH is analyzed. It appears that the neural mechanisms controlling GnRH gene expression in different physiological states may be distinct from those regulating GnRH/LH release. The hypothalamic GnRHR gene is probably located in different neural systems and may act in a specific way on GnRH gene expression and GnRH release.

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