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1,5-Dicarbonyl compounds:A general preparation method

Authors
Journal
Tetrahedron
0040-4020
Publisher
Elsevier
Publication Date
Volume
42
Issue
17
Identifiers
DOI: 10.1016/s0040-4020(01)82058-5

Abstract

Abstract In this report, a general method for the preparation of 1,5-dicarbonyl compounds and six membered ring annelation is described. This method involves the reaction of hemiacetal vinylogs 1 with enol ethers 2 or 3 in the presence of a Lewis acid. This reaction was successfully applied to the enol ethers of α and α,α'-hindered ketones such as 2,2,6-trimethyl cyclohexanone. α-Cyperone and 6-epi-α-cyperone were obtained using this process.

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