Abstract A geriatric health screening program in Dunedin, Florida, was used to evaluate risk factors leading to development of cataracts. A total of 2,787 participants completed the fourth yearly visit to the program. At the time of the fourth visit, 49.3% of women (mean age 75.1 years) and 38.2% of men (mean age 75.4 years) reported the presence of cataracts. Age was found to be the most significant risk factor in cataract development (P < .0001). Both men and women with cataracts had significantly lower serum cholesterol concentrations than subjects without cataracts. After adjusting for age and sex, diazepam (P < .03), furosemide (P < .04), isosorbide (P < .003), and ibuprofen (P < .03) were found to be positively associated with cataracts; triamterene (P < .05) had a negative association, indicating a protective relationship. Aspirin was not shown to have a protective effect on reported cataracts.