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Evidence for Involvement of β-Glucan-Binding Cell Surface Lectins in Human Natural Killer Cell Function

Authors
Journal
Cellular Immunology
0008-8749
Publisher
Elsevier
Publication Date
Volume
157
Issue
2
Identifiers
DOI: 10.1006/cimm.1994.1236

Abstract

Abstract We have studied the effects of yeast cell wall derivatives (zymosan and particulate β-glucan), on the cytolytic effector function of human natural killer cells. Both zymosan and particulate β-glucan were found to inhibit the NK-cell-mediated killing of K562, Molt-4, U937, and HL60 tumor cells. Zymosan also inhibited the IL-2-dependent proliferation of NK cells, suggesting that some component of the yeast cell wall delivers a down-modulatory signal affecting multiple NK cell functions. NK cell surface molecules capable of binding both zymosan and Sepharose-immobilized pustulan (linear 1,6-β-D-glucan, a carbohydrate component of zymosan and particulate β-glucan) were identified in detergent lysates prepared from surface iodinated NK cells. Our results suggest that NK cells express cell surface β-glucan-binding lectins that may contribute to NK-cell-mediated natural cytotoxicity.

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