Affordable Access

Optimization of a biomimetic bone cement: Role of DCPD

Authors
Journal
Journal of Inorganic Biochemistry
0162-0134
Publisher
Elsevier
Publication Date
Volume
105
Issue
8
Identifiers
DOI: 10.1016/j.jinorgbio.2011.05.006
Keywords
  • Calcium Phosphates
  • Bone Cement
  • Dicalcium Phosphate Dihydrate
  • Gelatin
Disciplines
  • Biology
  • Earth Science

Abstract

Abstract We previously proposed a biomimetic α-tricalcium phosphate (α-TCP) bone cement where gelatin controls the transformation of α-TCP into calcium deficient hydroxyapatite (CDHA), leading to improved mechanical properties. In this study we investigated the setting and hardening processes of biomimetic cements containing increasing amounts of CaHPO 4·2H 2O (DCPD) (0, 2.5, 5, 10, 15 wt.%), with the aim to optimize composition. Both initial and final setting times increased significantly when DCPD content accounts for 10 wt.%, whereas cements containing 15 wt.% DCPD did not set at all. Differential scanning calorimetry (DSC), X-ray diffraction (XRD), thermogravimetry (TG) and scanning electron microscopy (SEM) investigations were performed on samples maintained in physiological solution for different times. DCPD dissolution starts soon after cement preparation, but the rate of transformation decreases on increasing DCPD initial content in the samples. The rate of α-TCP to CDHA conversion during hardening decreases on increasing DCPD initial content. Moreover, the presence of DCPD prevents gelatin release during hardening. The combined effects of gelatin and DCPD on the rate of CDHA formation and porosity lead to significantly improved mechanical properties, with the best composition displaying a compressive strength of 35 MPa and a Young modulus of 1600 MPa.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Fiber reinforcement of a biomimetic bone cement.

on Journal of Materials Science M... June 2012

A biomimetic gelatin-calcium phosphate bone cement...

on The International journal of a... August 2004

Functionalization of biomimetic calcium phosphate...

on Journal of Inorganic Biochemis... Jan 01, 2010
More articles like this..