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Regulation of acetylcholine release in vivo from rat hippocampus by monoamines as revealed by novel column-switching HPLC with electrochemical detection

Authors
Journal
Brain Research
0006-8993
Publisher
Elsevier
Publication Date
Volume
572
Identifiers
DOI: 10.1016/0006-8993(92)90497-w
Keywords
  • Acetylcholine Release
  • Hippocampus
  • Brain Microdialysis
  • Noradrenaline
  • Dopamine
  • 5-Hydroxytryptamine

Abstract

Abstract To clarify monoaminergic regulation of acetylcholine (ACh) release in the rat hippocampus, the effects of administration of monoamines through a dialysis probe on extracellular ACh levels were examined using in vivo brain microdialyssi combined with a novel column-switching HPLC system. Infusion of dopamine or 5-hydeoxytryptamine, but not noradrenaline, increased ACh levels. The ACh levels also increased following infusion of apomorphine and 5-methoxy- N,N-dimethyltryptamine. These results demonstrate that hippocampal ACh release is regulated by dopamine and 5-hydroxytryptamine.

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