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Steric exclusion and partial exclusion by polymer incompatibility in gel permeation chromatography

Authors
Journal
Polymer
0032-3861
Publisher
Elsevier
Publication Date
Volume
19
Issue
6
Identifiers
DOI: 10.1016/0032-3861(78)90126-x
Disciplines
  • Physics

Abstract

Abstract The early elution of some polymers in gel permeation chromatography is represented by a network-limited mechanism involving a distribution coefficient, K D , for steric exclusion and a distribution coefficient, K P , for solute-gel interactions. Values of K P below unity correspond to partial exclusion by polymer incompatibility with the gel. A thermodynamic treatment for K P is presented, predicting that K P decreases as molecular weight increases. Values of K P determined from experimental results reported for separations of poly(vinyl acetate) and polyoxyethylene are in the direction predicted by the theoretical treatment for partial exclusion by polymer incompatibility.

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