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Target discovery.

Authors
Journal
Nature Reviews Drug Discovery
1474-1776
Publisher
Nature Publishing Group
Publication Date
Keywords
  • Animals
  • Disease Models
  • Animal
  • Drug Design
  • Drug Evaluation
  • Preclinical
  • Gene Expression Profiling
  • Gene Silencing
  • Genome
  • Human
  • Genomics
  • Humans
  • Oligonucleotide Array Sequence Analysis
  • Proteomics
  • Rna
  • Small Interfering
Disciplines
  • Biology
  • Medicine

Abstract

Target discovery, which involves the identification and early validation of disease-modifying targets, is an essential first step in the drug discovery pipeline. Indeed, the drive to determine protein function has been stimulated, both in industry and academia, by the completion of the human genome project. In this article, we critically examine the strategies and methodologies used for both the identification and validation of disease-relevant proteins. In particular, we will examine the likely impact of recent technological advances, including genomics, proteomics, small interfering RNA and mouse knockout models, and conclude by speculating on future trends.

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