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Evolution of mollicutes: down a bumpy road with twists and turns

Authors
Journal
Research in Microbiology
0923-2508
Publisher
Elsevier
Publication Date
Volume
158
Issue
10
Identifiers
DOI: 10.1016/j.resmic.2007.09.007
Keywords
  • Mycoplasma
  • Low Gc Genomes
  • Genome Evolution
  • Horizontal Gene Transfer

Abstract

Abstract Mollicute evolution has been marked by significant changes in genome structure and use of their genetic information. These include a reduction in their genome G + C content and the use by most mollicutes of the UGA universal stop codon as tryptophan. More striking is the size reduction in their genome which, for some species, is now close to the minimal requirement for sustaining cell life. With the growing body of sequence data, a new picture has recently begun to emerge in which the evolution of these simple bacteria cannot be reduced to a race for the smallest genome.

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